If you've used pretty much any version of Adobe Photoshop before, you won't have any trouble getting around in this CS6 version, especially if you've used CS4/CS5 before. The same interface and design in Adobe Photoshop CS6 Extended is used as it was in the earlier iteration of the Adobe services with CS5.
Photoshop CS6 has some surprises in-store for users even familiar with CS4 including wet brushes, content-aware healing brushes, a smart selection tool and content-aware background filling.
As with previous versions of Adobe Photoshop, usage is streamlined and when you have an idea of what you're doing, CS6 improves on the already minimalist design of Adobe Photoshop CS5.
System Resource usage on CS6 is extremely well-improved with their support of 64-bit operating systems. Though your system might be bogged down by having multiple windows open and especially working with a ton of layers, this version does improve on what CS4, CS3 and before that stumbled on.
With the menus have been changed slightly with Adobe Photoshop CS6, it didn't take very long for us to get used to the new arrangements (which were actually minimal). Thankfully, keyboard shortcuts remain traditional to older versions. If you haven't used Photoshop before or you are not a seasoned user, we highly recommend getting used to some of the keyboard shortcuts as this can shave a load of time off of whatever task you're working on.
One thing about Adobe Photoshop CS6 Extended that we were impressed with was their improved handling of text. When comparing to older versions, it appears that rendering of fonts has become sharper and less pixelated than what we're used to with Adobe Photoshop versions before this.
While Photoshop isn't the easiest program to get used to, there is a steep learning curve involved but when you're past that, this is the best photo editing suite we've ever seen. The learning curve for Adobe Photoshop has become less stressful with this iteration as the menus and design has become more minimalist. The online help available from Adobe.com certainly help new and seasoned Photoshop users.